Cardiac xenotransplantation in primates

Pig-to-Nonhuman Primates Pancreatic Islet Xenotransplantation: An Overview

The therapy of type 1 diabetes is an open challenging problem. The restoration of normoglycemia and insulin independence in immunosuppressed type 1 diabetic recipients of islet allotransplantation has shown the potential of a cell-based diabetes therapy. Even if successful, this approach poses a problem of scarce tissue supply. Xenotransplantation can be the answer to this limited donor availab...

Discordant cardiac xenotransplantation: broadening the horizons.

a Transregio Collaborative Research Center 127, Ludwig-Maximilians University, Munich, Germany b Department of Cardiovascular Surgery, Ludwig-Maximilians University, Munich, Germany c Revivicor, Blacksburg, VA, USA d Living Cell Technologies, Auckland, New Zealand e Chair of Livestock Biotechnology, Weihenstephan, Technical University, Munich, Germany f Department of Anaesthesiology and Intensi...

Cardiac xenotransplantation: clinical experience and future direction.

The shortage of human organs has focused research on finding an animal source of replacement organs. The immunological barriers to xenotransplantation are now more clearly defined, allowing retrospective interpretation of past clinical experience in humans. Due to physiological compatibilities as well as ethical and infectious considerations, pigs have now emerged as the most likely source of f...

Xenotransplantation of embryonic pig pancreas for treatment of diabetes mellitus in non-human primates.

Transplantation therapy for diabetes in humans is limited by the low availability of human donor whole pancreas or islets. Outcomes are complicated by immunosuppressive drug toxicity. Xenotransplantation is a strategy to overcome supply problems. Implantation of tissue obtained early during embryogenesis is a way to reduce transplant immunogenicity. Pig insulin is biologically active in humans....

Vascularized Thymosternal Composite Tissue Allo- and Xenotransplantation in Nonhuman Primates: Initial Experience